
projects
see the list of main projects run in the lab.
15.02.2021. Kasia got NCN MAESTRO grant! Neuronal basis of spatial choice.
14.01.2021. Kasia is full professor now. Congratulations!
30.11.2020. We have a new paper on bioRxiv. PSD-95 in dorsal CA1 contributes to the persistence of fear memory
30.10.2020. We have a new paper on synaptic plasticity and ageing accepted in Journal of Neurosci. Congratulations to all authors!
It remains poorly understood how ageing affects behavioural and molecular processes that support cognitive functions. It is, however, essential to understand these processes in order to develop therapeutic interventions that support successful cognitive ageing. Our data indicate that while young mice require PSD-95-dependent synaptic plasticity in dCA1 to make correct spatial choices (i.e. choices that require spatial information), old animals observe cage-mates and stick to a preferred corner to seek the reward. This strategy is resistant to the depletion of PSD-95 in the CA1 area. Overall, our study demonstrates that aged mice combine alternative behavioral and molecular strategies to approach and consume rewards in a complex environment. Secondly, the contribution of PSD-95-dependent synaptic functions in spatial choice changes with age.
01.10.2020. We have a new technicien in the lab. Welcome, Asia Frączek!
18.06.2020. Roberto Pagano just defended his thesis! Congratulations!
18.06.2020. Maria Nalberczak-Skóra just defended her thesis! Congratulations!
10.10.2019. She is not really from our team but... OLGA TOKARCZUK GOT THE NOBEL PRIZE!
01.05.2020. Kamil got PRELUDIUM grant! Congratulations! Do excitatory projections from nucleus reuniens to medial septum control remote fear memory extinction?
01.10.2019. We have a new PhD student. Welcome, Edyta Skonieczna!
30.09.2019. We have a paper accepted in Cerebral Cortex. Congratulations to all authors!
It is generally accepted that formation and storage of memory relies on alterations of the structure and function of brain circuits. However, the structural data, which show learning-induced and long-lasting remodeling of synapses, are still very sparse. Here, we reconstruct 1927 dendritic spines and their postsynaptic densities (PSDs), representing a postsynaptic part of the glutamatergic synapse, in the hippocampal area CA1 of the mice that underwent spatial training. We observe that in young adult (5 months), mice volume of PSDs, but not the volume of the spines, is increased 26 h after the training. The training-induced growth of PSDs is specific for the dendritic spines that lack smooth endoplasmic reticulum and spine apparatuses, and requires autophosphorylation of αCaMKII. Interestingly, aging alters training-induced ultrastructural remodeling of dendritic spines. In old mice, both the median volumes of dendritic spines and PSDs shift after training toward bigger values. Overall, our data support the hypothesis that formation of memory leaves long-lasting footprint on the ultrastructure of brain circuits; however, the form of circuit remodeling changes with age.
27.09.2019. We got Jerzy Konorski prize for 2019!
The commission appointed by the Neurobiology Committee of the Polish Academy of Sciences and the Polish Neuroscience Society leaded by the professor Marian Lewandowski decided to award the Jerzy Konorski prize for 2019 to the paper Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction published by Anna Beroun, Maria Nalberczak-Skóra, Zofia Harda, Małgorzata Piechota, Magdalena Ziółkowska, Anna Pełka, Roberto Pagano and Kasia Radwańska (Neuropsychopharmacology, 2019; vol. 43, 1989–1999) doi: 10.1038/s41386-018-0119-4
26.09.2019. Gosia Borczyk just defended her thesis summa cum laude! Congratulations! 18.09.2019. Kaceper Łukasiewicz just defended his thesis! Congratulations!see the list of main projects run in the lab.
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